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 | Acesso ao texto completo restrito à biblioteca da Embrapa Gado de Leite. Para informações adicionais entre em contato com cnpgl.biblioteca@embrapa.br. |
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Registro Completo |
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Biblioteca(s): |
Embrapa Gado de Leite. |
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Data corrente: |
01/12/2023 |
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Data da última atualização: |
15/02/2024 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
CARRARA, E. R.; LOPES, P. S.; VERONEZE, R.; PEREIRA, R. J.; ZADRA, L. E. F.; PEIXOTO, M. G. C. D. |
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Afiliação: |
UNIVERSIDADE FEDERAL DE VIÇOSA; UNIVERSIDADE FEDERAL DE VIÇOSA; UNIVERSIDADE FEDERAL DE VIÇOSA; UNIVERSIDADE FEDERAL DE RONDONÓPOLIS; CENTRO BRASILEIRO DE MELHORAMENTO GENÉTICO DO GUZERÁ; MARIA GABRIELA CAMPOLINA DINIZ PEIX, CNPGL. |
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Título: |
Assessment of runs of homozygosity, heterozygosity-rich regions and genomic inbreeding estimates in a subpopulation of Guzerá (Bos indicus) dual-purpose cattle. |
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Ano de publicação: |
2024 |
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Fonte/Imprenta: |
Journal of Animal Breeding and Genetics, v. 141, n. 2, p. 207-219, 2024. |
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DOI: |
https://doi.org/10.1111/jbg.12836 |
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Idioma: |
Inglês |
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Conteúdo: |
For decades, inbreeding in cattle has been evaluated using pedigree information. Nowadays, inbreeding coefficients can be obtained using genomic information such as runs of homozygosity (ROH). The aims of this study were to quantify ROH and heterozygosity-rich regions (HRR) in a subpopulation of Guzerá dual-purpose cattle, to examine ROH and HRR islands, and to compare inbreeding coefficients obtained by ROH with alternative genomic inbreeding coefficients. A subpopulation of 1733 Guzerá animals genotyped for 50k SNPs was used to obtain the ROH and HRR segments. Inbreeding coefficients by ROH (FROH), by genomic relationship matrix based on VanRaden's method 1 using reference allele frequency in the population (FGRM), by genomic relationship matrix based on VanRaden's method 1 using allele frequency fixed in 0.5 (FGRM_0.5), and by the proportion of homozygous loci (FHOM) were calculated. A total of 15,660 ROH were identified, and the chromosome with the highest number of ROH was BTA6. A total of 4843 HRRs were identified, and the chromosome with the highest number of HRRs was BTA23. No ROH and HRR islands were identified according to established criteria, but the regions closest to the definition of an island were examined from 64 to 67 Mb of BTA6, from 36 to 37 Mb of BTA2 and from 0.50 to 1.25 Mb of BTA23. The genes identified in ROH islands have previously been associated with dairy and beef traits, while genes identified on HRR islands have previously been associated with reproductive traits and disease resistance. FROH was equal to 0.095 ± 0.084, and its Spearman correlation with FGRM was low (0.44) and moderate-high with FHOM (0.79) and with FGRM_0.5 (0.80). The inbreeding coefficients determined by ROH were higher than other cattle breeds' and higher than pedigree-based inbreeding in the Guzerá breed obtained in previous studies. It is recommended that future studies investigate the effects of inbreeding determined by ROH on the traits under selection in the subpopulation studied. MenosFor decades, inbreeding in cattle has been evaluated using pedigree information. Nowadays, inbreeding coefficients can be obtained using genomic information such as runs of homozygosity (ROH). The aims of this study were to quantify ROH and heterozygosity-rich regions (HRR) in a subpopulation of Guzerá dual-purpose cattle, to examine ROH and HRR islands, and to compare inbreeding coefficients obtained by ROH with alternative genomic inbreeding coefficients. A subpopulation of 1733 Guzerá animals genotyped for 50k SNPs was used to obtain the ROH and HRR segments. Inbreeding coefficients by ROH (FROH), by genomic relationship matrix based on VanRaden's method 1 using reference allele frequency in the population (FGRM), by genomic relationship matrix based on VanRaden's method 1 using allele frequency fixed in 0.5 (FGRM_0.5), and by the proportion of homozygous loci (FHOM) were calculated. A total of 15,660 ROH were identified, and the chromosome with the highest number of ROH was BTA6. A total of 4843 HRRs were identified, and the chromosome with the highest number of HRRs was BTA23. No ROH and HRR islands were identified according to established criteria, but the regions closest to the definition of an island were examined from 64 to 67 Mb of BTA6, from 36 to 37 Mb of BTA2 and from 0.50 to 1.25 Mb of BTA23. The genes identified in ROH islands have previously been associated with dairy and beef traits, while genes identified on HRR islands have previously been associated with ... Mostrar Tudo |
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Palavras-Chave: |
Autozigosidade; Autozygosity. |
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Thesagro: |
Bovino; Gado de Corte; Gado Guzerá; Gado Leiteiro; Marcador Genético. |
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Thesaurus Nal: |
Beef cattle; Dairy cattle; Genetic markers; Zebu. |
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Categoria do assunto: |
L Ciência Animal e Produtos de Origem Animal |
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Marc: |
LEADER 03045naa a2200325 a 4500
001 2159024
005 2024-02-15
008 2024 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.1111/jbg.12836$2DOI
100 1 $aCARRARA, E. R.
245 $aAssessment of runs of homozygosity, heterozygosity-rich regions and genomic inbreeding estimates in a subpopulation of Guzerá (Bos indicus) dual-purpose cattle.$h[electronic resource]
260 $c2024
520 $aFor decades, inbreeding in cattle has been evaluated using pedigree information. Nowadays, inbreeding coefficients can be obtained using genomic information such as runs of homozygosity (ROH). The aims of this study were to quantify ROH and heterozygosity-rich regions (HRR) in a subpopulation of Guzerá dual-purpose cattle, to examine ROH and HRR islands, and to compare inbreeding coefficients obtained by ROH with alternative genomic inbreeding coefficients. A subpopulation of 1733 Guzerá animals genotyped for 50k SNPs was used to obtain the ROH and HRR segments. Inbreeding coefficients by ROH (FROH), by genomic relationship matrix based on VanRaden's method 1 using reference allele frequency in the population (FGRM), by genomic relationship matrix based on VanRaden's method 1 using allele frequency fixed in 0.5 (FGRM_0.5), and by the proportion of homozygous loci (FHOM) were calculated. A total of 15,660 ROH were identified, and the chromosome with the highest number of ROH was BTA6. A total of 4843 HRRs were identified, and the chromosome with the highest number of HRRs was BTA23. No ROH and HRR islands were identified according to established criteria, but the regions closest to the definition of an island were examined from 64 to 67 Mb of BTA6, from 36 to 37 Mb of BTA2 and from 0.50 to 1.25 Mb of BTA23. The genes identified in ROH islands have previously been associated with dairy and beef traits, while genes identified on HRR islands have previously been associated with reproductive traits and disease resistance. FROH was equal to 0.095 ± 0.084, and its Spearman correlation with FGRM was low (0.44) and moderate-high with FHOM (0.79) and with FGRM_0.5 (0.80). The inbreeding coefficients determined by ROH were higher than other cattle breeds' and higher than pedigree-based inbreeding in the Guzerá breed obtained in previous studies. It is recommended that future studies investigate the effects of inbreeding determined by ROH on the traits under selection in the subpopulation studied.
650 $aBeef cattle
650 $aDairy cattle
650 $aGenetic markers
650 $aZebu
650 $aBovino
650 $aGado de Corte
650 $aGado Guzerá
650 $aGado Leiteiro
650 $aMarcador Genético
653 $aAutozigosidade
653 $aAutozygosity
700 1 $aLOPES, P. S.
700 1 $aVERONEZE, R.
700 1 $aPEREIRA, R. J.
700 1 $aZADRA, L. E. F.
700 1 $aPEIXOTO, M. G. C. D.
773 $tJournal of Animal Breeding and Genetics$gv. 141, n. 2, p. 207-219, 2024.
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Registro original: |
Embrapa Gado de Leite (CNPGL) |
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Biblioteca |
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| Registros recuperados : 13 | |
| 1. |  | CARRARA, E. R.; LOPES, P. S.; VERONEZE, R.; PEREIRA, R. J.; ZADRA, L. E. F.; PEIXOTO, M. G. C. D. Assessment of runs of homozygosity, heterozygosity-rich regions and genomic inbreeding estimates in a subpopulation of Guzerá (Bos indicus) dual-purpose cattle. Journal of Animal Breeding and Genetics, v. 141, n. 2, p. 207-219, 2024.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 1 |
| Biblioteca(s): Embrapa Gado de Leite. |
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| 2. | | LIGORI, V. A.; CARDOSO, V. L.; PEIXOTO, M. G. C. D.; BRUNELI, F. A. T.; ZADRA, L. E. F. Economic values for milk production and quality traits of Guzerá cattle in Brazil. In: REUNIÃO ANUAL DA SOCIEDADE BRASILEIRA DE ZOOTECNIA, 56., 2021, Florianópolis. Animal science: challenges in production and sustainability: proceedings... Brasília, DF: Sociedade Brasileira de Zootecnia, 2021. p. 312. Evento virtual.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Gado de Leite. |
|  |
| 3. | | LIGORI, V. A.; CARDOSO, V. L.; PEIXOTO, M. G. C. D.; BRUNELI, F. A. T.; CARRARA, E. R.; ZADRA, L. E. F. Selection indexes for dairy traits in Guzera breed in Brazil. In: REUNIÃO DA SOCIEDADE BRASILEIRA DE ZOOTECNIA, 57., 2022, Campinas. Tropical animal science and pratice to feed the planet: proceedings. Brasília, DF: Sociedade Brasileira de Zootecnia; São Carlos, SP: Embrapa Pecuária Sudeste, 2022. p. 281.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Gado de Leite. |
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| 4. | | CARRARA, E. R.; PEIXOTO, M. G. C. D.; SILVA, A. A. da; BRUNELI, F. A. T.; VENTURA, H. T.; ZADRA, L. E. F.; JOSAHKIAN, L. A.; VERONEZE, R.; LOPES, P. S. Genomic prediction in Brazilian Guzerá cattle: application of a single-step approach to productive and reproductive traits. Tropical Animal Health and Production, v. 55, article 48, 2023.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 2 |
| Biblioteca(s): Embrapa Gado de Leite. |
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| 5. | | CARRARA, E. R.; PEIXOTO, M. G. C. D.; VERONEZE, R.; SILVA, F. F. e; RAMOS, P. V. B.; BRUNELI, F. A. T.; ZADRA, L. E. F.; VENTURA, H. T.; JOSAHKIAN, L. A.; LOPES, P. S. Genetic study of quantitative traits supports the use of Guzerá as dual-purpose cattle. Animal Bioscience, v. 35, n. 7, p. 955-963, 2022.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: B - 5 |
| Biblioteca(s): Embrapa Gado de Leite. |
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| 6. | | BRUNELI, F. A. T.; PEIXOTO, M. G. C. D.; SANTANA JUNIOR, M. L.; PEREIRA, R. J.; ARBEX, W. A.; PENNA, V. M.; ZADRA, L. E. F.; VERNEQUE, R. da S.; LÔBO, R. B.; CARVALHO, M. R. S. (ed.). Programa Nacional de Melhoramento do Guzerá para Leite: resultados do Teste de Progênie, do Arquivo Zootécnico Nacional e do Núcleo MOET. Juiz de Fora: Embrapa Gado de Leite, 2021. 93 p. (Embrapa Gado de Leite. Documentos, 256).| Biblioteca(s): Embrapa Gado de Leite. |
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| 7. | | BRUNELI, F. A. T.; PEIXOTO, M. G. C. D.; SANTANA JUNIOR, M. L.; PEREIRA, R. J.; ARBEX, W. A.; PENNA, V. M.; ZADRA, L. E. F.; JOSAHKIAN, L. A.; VERNEQUE, R. da S.; LÔBO, R. B.; CARVALHO, M. R. S. Programa Nacional de Melhoramento do Guzerá para Leite: resultados do Teste de Progênie, do Programa de Melhoramento Genético de Zebuínos da ABCZ e do Núcleo MOET. Juiz de Fora: Embrapa Gado de Leite, 2019. 92 p. (Embrapa Gado de Leite. Documentos, 237).| Biblioteca(s): Embrapa Gado de Leite. |
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| 8. | | BRUNELI, F. A. T.; PEIXOTO, M. G. C. D.; SANTANA JUNIOR, M. L.; PEREIRA, R. J.; ARBEX, W. A.; PENNA, V. M.; ZADRA, L. E. F.; JOSAHKIAN, L. A.; VERNEQUE, R. da S.; LÔBO, R. B.; CARVALHO, M. R. S. Programa Nacional de Melhoramento do Guzerá para Leite: resultados do Teste de Progênie, do Programa de Melhoramento Genético de Zebuínos da ABCZ e do Núcleo MOET. Juiz de Fora: Embrapa Gado de Leite, 2020. 102 p. (Embrapa Gado de Leite. Documentos, 249).| Biblioteca(s): Embrapa Gado de Leite. |
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| 9. | | BRUNELI, F. A. T.; PEIXOTO, M. G. C. D.; SANTANA JUNIOR, M. L.; PEREIRA, R. J.; ARBEX, W. A.; PENNA, V. M.; ZADRA, L. E. F.; VERNEQUE, R. da S.; LÔBO, R. B.; CARVALHO, M. R. S. (ed.). National Breeding Program of Guzerá Cattle for Milk: Progeny Testing, National Zootechnical Archive and MOET Nucleus Results. Juiz de Fora: Embrapa Gado de Leite, 2020 102 p. (Embrapa Gado de Leite. Documentos, 251).| Biblioteca(s): Embrapa Gado de Leite. |
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| 10. | | BRUNELI, F. A. T.; PEIXOTO, M. G. C. D.; SANTANA JÚNIOR, M. L.; PEREIRA, R. J.; ARBEX, W. A.; PENNA, V. M.; ZADRA, L. E. F.; VERNEQUE, R. da S.; LÔBO, R. B.; CARVALHO, M. R. S. (ed.). National Breeding Program of Guzerá Cattle for Milk: progeny testing, National Zootechnical Archive and MOET nucleus results. Juiz de Fora: Embrapa Gado de Leite, 2021. 92 p. (Embrapa Gado de Leite. Documentos, 258).| Biblioteca(s): Embrapa Gado de Leite. |
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| 11. | | BRUNELI, F. A. T.; PEIXOTO, M. G. C. D.; SANTANA JUNIOR, M. L.; PEREIRA, R. J.; ARBEX, W. A.; PENNA, V. M.; ZADRA, L. E. F.; VERNEQUE, R. da S.; LÔBO, R. B.; CARVALHO, M. R. S. (ed.). Programa Nacional de Mejoramiento de Guzerá para Leche: Resultados de la Prueba de Progenie, del Archivo Zootécnico Nacional y del Núcleo MOET. Juiz de Fora: Embrapa Gado de Leite, 2020. 102 p. (Embrapa Gado de Leite. Documentos, 250).| Biblioteca(s): Embrapa Gado de Leite. |
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| 12. | | BRUNELI, F. A. T.; PEIXOTO, M. G. C. D.; SANTANA JUNIOR, M. L.; PEREIRA, R. J.; ARBEX, W. A.; PENNA, V. M.; ZADRA, L. E. F.; VERNEQUE, R. da S.; LÔBO, R. B.; CARVALHO, M. R. S. (ed.). Programa Nacional de Mejoramiento de Guzerá para Leche: resultados de la prueba de progenie, del Archivo Zootécnico Nacional y del núcleo MOET. Juiz de Fora: Embrapa Gado de Leite, 2021. 96 p. (Embrapa Gado de Leite. Documentos, 257).| Biblioteca(s): Embrapa Gado de Leite. |
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| 13. | | BRUNELI, F. A. T.; PEIXOTO, M. G. C. D.; SANTOS, G. G. dos; ARBEX, W. A.; PENNA, V. M.; ZADRA, L. E. F.; JOSAHKIAN, L. A.; VERNEQUE, R. da S.; MACHADO, M. A.; PANETTO, J. C. do C.; LÔBO, R. B.; CARVALHO, M. R. S. Programa Nacional de Melhoramento do Guzerá para Leite: resultados do Teste de Progênie, do Programa de Melhoramento Genético de Zebuínos da ABCZ e do Núcleo MOET. Juiz de Fora: Embrapa Gado de Leite, 2018. 77 p. (Embrapa Gado de Leite. Documentos, 218).| Biblioteca(s): Embrapa Gado de Leite. |
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| Registros recuperados : 13 | |
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| Nenhum registro encontrado para a expressão de busca informada. |
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